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A M Al-Katib Selected Research

bryostatin 1

12/2001Mitogen-activated protein kinase is required for bryostatin 1-induced differentiation of the human acute lymphoblastic leukemia cell line Reh.
1/2001Phase II study of bryostatin 1 in patients with relapsed multiple myeloma.
1/2001Treatment-induced expression of anti-apoptotic proteins in WSU-CLL, a human chronic lymphocytic leukemia cell line.
12/2000The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy improves response in a CHOP-resistant human diffuse large cell lymphoma xenograft model.
4/2000Bryostatin 1-induced modulation of nucleoside transporters and 2-chlorodeoxyadenosine influx in WSU-CLL cells.
4/2000Sequential treatment of a resistant chronic lymphocytic leukemia patient with bryostatin 1 followed by 2-chlorodeoxyadenosine: case report.
3/2000Phase II trial of bryostatin 1 in patients with relapsed low-grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
2/2000Bryostatin 1 induces ubiquitination and proteasome degradation of Bcl-2 in the human acute lymphoblastic leukemia cell line, Reh.

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A M Al-Katib Research Topics

Disease

4Neoplasms (Cancer)
01/2001 - 03/2000
4B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
01/2001 - 03/2000
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
12/2001 - 02/2000
2Non-Hodgkin Lymphoma (Lymphosarcoma)
01/2001 - 03/2000
1Lymphoid Leukemia
12/2001
1Multiple Myeloma
01/2001
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
12/2000
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
12/2000
1Hairy Cell Leukemia
04/2000
1Leukemia
03/2000

Drug/Important Bio-Agent (IBA)

8bryostatin 1IBA
12/2001 - 02/2000
2Proteins (Proteins, Gene)FDA Link
12/2001 - 02/2000
2Protein Kinase CIBA
01/2001 - 12/2000
2CladribineFDA LinkGeneric
04/2000 - 04/2000
1MitogensIBA
12/2001
1Mitogen-Activated Protein KinasesIBA
12/2001
1BryostatinsIBA
12/2001
1Phosphotransferases (Kinase)IBA
12/2001
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
12/2001
1fosbretabulin (combretastatin A4)IBA
01/2001
1Apoptosis Regulatory ProteinsIBA
01/2001
1LactonesIBA
01/2001
1ProdrugsIBA
01/2001
1Prednisone (Sone)FDA LinkGeneric
12/2000
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
12/2000
1Doxorubicin (Adriamycin)FDA LinkGeneric
12/2000
1Vincristine (Oncovin)FDA LinkGeneric
12/2000
1fludarabineIBA
04/2000
1Nucleoside Transport Proteins (Nucleoside Transporter)IBA
04/2000
1purineIBA
04/2000
1Proteasome Endopeptidase Complex (Proteasome)IBA
02/2000

Therapy/Procedure

1Therapeutics
01/2001
1VAP-cyclo protocol
12/2000
1Drug Therapy (Chemotherapy)
12/2000